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商品編號


3666/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Polymerases



Size

10 mg

商品信息

Description:
Reverse transcriptase inhibitor

Alternative Names:
PMPA, (
R
)-9-(2-Phosphonoylmethoxypropyl)adenine

Chemical Name:
(
R
)-[[2-(6-Amino-9
H
-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells
in vitro
(IC
50
= 1.5
μ
M). Antiviral agent.



Technical Data



M. Wt

287.21



Formula

C
9
H
14
N
5
O
4
P



Storage

Store at -20°C



Purity

≥99% (HPLC)



CAS Number

147127-20-6



PubChem ID

464205



InChI Key

SGOIRFVFHAKUTI-ZCFIWIBFSA-N



Smiles

C[C@@H](OCP(O)(O)=O)CN(C=N2)C1=C2C(N)=NC=N1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



1.1eq. NaOH

28.72

100



DMSO

2.87

10





Preparing Stock Solutions

The following data is based on the
product
molecular weight
287.21
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.48 mL

17.41 mL

34.82 mL



5 mM

0.7 mL

3.48 mL

6.96 mL



10 mM

0.35 mL

1.74 mL

3.48 mL



50 mM

0.07 mL

0.35 mL

0.7 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Tsai

et al
(1995) Prevention of SIV infection in macaques by (
R
)-9-(2-phosphonylmethoxypropyl)adenine. Science
270
1197 PMID: 7502044


Van Rompay

et al
(1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother.
40
2586 PMID: 8913470


Suo

et al
(1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (
R
)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem.
273
27250 PMID: 9765248




Keywords: Tenofovir, supplier, Reverse, transcriptase, inhibitors, inhibits, Polymerases, RNA/DNA, Polymerase, antivirals, antiretrovirals, PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine, RNA/DNA, Polymerase, Antivirals, RNA/DNA, Polymerase,
Tocris
Bioscience