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商品編號


3365/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Ligases



Size

50 mg

商品信息

Description:
Protects against MDM2-mediated p53 degradation

Chemical Name:

N
-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21
CIP/WAF1
and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity
in vitro
.



Compound Libraries

Tenovin-1 is also offered as part of the
Tocris
creen Plus and
Tocris
creen Epigenetics Toolbox. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

369.48



Formula

C
20
H
23
N
3
O
2
S



Storage

Store at +4°C



Purity

≥99% (HPLC)



CAS Number

380315-80-0



PubChem ID

1013376



InChI Key

WOWJIWFCOPZFGV-UHFFFAOYSA-N



Smiles

CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C)=O)C=C2)=S)=O)C=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

9.24

25



ethanol

1.85

5





Preparing Stock Solutions

The following data is based on the
product
molecular weight
369.48
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.71 mL

13.53 mL

27.07 mL



5 mM

0.54 mL

2.71 mL

5.41 mL



10 mM

0.27 mL

1.35 mL

2.71 mL



50 mM

0.05 mL

0.27 mL

0.54 mL






Molarity Calculator






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Dilution Calculator






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Lain

et al
(2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell
13
454 PMID: 18455128




Keywords: Tenovin-1, supplier, activators, p53, transcriptional, activity, Protects, against, MDM2-mediated, degradation, Transcription, Factors, Ligases, p53, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience