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商品編號


0652/100



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Ligases



Size

100 mg

商品信息

Description:
Binds cereblon, inhibiting ubiquitin ligase activity; alsoTNF-a synthesis inhibitor

Chemical Name:

N
-(2,6-dioxo-3-piperidinyl)phthalimide

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Selective inhibitor of tumor necrosis factor
α
(TNF-
α
) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties.



Technical Data



M. Wt

258.23



Formula

C
13
H
10
N
2
O
4




Storage

Store at RT



Purity

≥99% (HPLC)



CAS Number

50-35-1



PubChem ID

5426



InChI Key

UEJJHQNACJXSKW-UHFFFAOYSA-N



Smiles

O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C1C=CC=C2



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

6.46

25





Preparing Stock Solutions

The following data is based on the
product
molecular weight
258.23
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.87 mL

19.36 mL

38.73 mL



5 mM

0.77 mL

3.87 mL

7.75 mL



10 mM

0.39 mL

1.94 mL

3.87 mL



50 mM

0.08 mL

0.39 mL

0.77 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Boireau

et al
(1997) Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice. Neurosci.Lett.
234
123 PMID: 9364513


Kanbayashi

et al
(1996) Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport
7
1881 PMID: 8905685


Makonkawkeyoon

et al
(1993) Thalidomide inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A.
90
5974 PMID: 8327469


Zhang

et al
(2008) Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res.
27
60 PMID: 18983651


Sampaio

et al
(1991) Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med.
173
699 PMID: 1997652



Merck
Index
12
9390 PMID:


Ito

et al
(2010) Identification of a primary target of thalidomide teratogenicity. Science
327
1345 PMID: 20223979




Keywords: Thalidomide, supplier, TNF-α, TNF-alpha, synthesis, inhibitors, inhibits, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Signaling, Signalling, teratogen, anti-inflammatory, angiogenesis, cereblon, ubiquitin, E3, ligase, Cytokines, Antiangiogenics, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience