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商品編號


3736/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Polymerases



Size

10 mg

商品信息

Description:
PARP-2 inhibitor

Chemical Name:
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2
H
)-one

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC
50
values are 0.3 and 8.0
μ
M for PARP-2 and PARP-1 respectively).



Compound Libraries

UPF 1069 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

279.29



Formula

C
17
H
13
NO
3




Storage

Store at RT



Purity

≥99% (HPLC)



CAS Number

1048371-03-4



PubChem ID

25015515



InChI Key

JJWMRRNGWSITSQ-UHFFFAOYSA-N



Smiles

O=C2NC=CC1=C(OCC(C3=CC=CC=C3)=O)C=CC=C12



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

27.93

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
279.29
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.58 mL

17.9 mL

35.81 mL



5 mM

0.72 mL

3.58 mL

7.16 mL



10 mM

0.36 mL

1.79 mL

3.58 mL



50 mM

0.07 mL

0.36 mL

0.72 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Moroni

et al
(2009) Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br.J.Pharmacol.
157
854 PMID: 19422384


Pellicciari

et al
(2008) On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives. Chem.Med.Chem
3
914 PMID:




Keywords: UPF 1069, supplier, PARP2, poly(ADP-ribose), polymerases, inhibitors, inhibits, UPF1069, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase,
Tocris
Bioscience