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Tocris/XAV 939/3748/10/10 mg

克隆和表達
Tocris/XAV 939/3748/10/10 mg


商品編號


3748/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Polymerases



Size

10 mg

商品信息

Description:
Potent tankyrase inhibitor

Chemical Name:
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4
H
-thiopyrano[4,3-
d
]pyrimidin-4-one

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Potent tankyrase (TNKS) inhibitor (IC
50
values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of
β
-catenin degradation and st
ABI
lization of axin. Inhibits proliferation of the
β
-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm
Progen
itor cells.



External Portal Information

Chemicalprobes.org
is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of XAV939 is reviewed on the chemical probes website.



Compound Libraries

XAV 939 is also offered as part of the
Tocris
creen Plus and
Tocris
creen Stem Cell Toolbox. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

312.31



Formula

C
14
H
11
F
3
N
2
OS



Storage

Store at RT



Purity

≥98% (HPLC)



CAS Number

284028-89-3



PubChem ID

2726824



InChI Key

KLGQSVMIPOVQAX-UHFFFAOYSA-N



Smiles

OC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

6.25

20





Preparing Stock Solutions

The following data is based on the
product
molecular weight
312.31
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.2 mL

16.01 mL

32.02 mL



5 mM

0.64 mL

3.2 mL

6.4 mL



10 mM

0.32 mL

1.6 mL

3.2 mL



50 mM

0.06 mL

0.32 mL

0.64 mL






Molarity Calculator






Molarity Calculator

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Reconstitution Calculator






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Dilution Calculator






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

Select another language:



English
German
French
Spanish

View SDS





References

References are publications that support the products'
BIOLOG
ical activity.


Huang

et al
(2009) Tankyrase inhibition st
ABI
lizes axin and antagonizes wnt signalling. Nature
461
614 PMID: 19759537


Adler
(2009) Inhibiting wnt signaling. Sci.Signal.
91
PMID:


Wang

et al
(2010) Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/
β
-catenin signaling. ACS Chem. Biol.
6
192 PMID: 21077691




Keywords: XAV 939, supplier, XAV939, wnt, signalling, signaling, b-catenin, β-catenin, beta-catenin, axin, TNKS1, TNKS2, tankyrase, inhibitors, inhibits, PARP, poly(ADP-ribose), polymerases, cardiogenesis, Beta-catenin, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, Tankyrase,
Tocris
Bioscience


上一篇 BBI Solutions/Glucose Dehydrogenase (FAD-dependent) - reduced xylose interference//GLD3  下一篇 Tocris/UPF 1069/3736/50/50 mg

產(chǎn)品貨號:1792.8

1792.8 ¥
11至15個(gè)工作日送達
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